Author

J. Fowles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

H. Celik· 2 shared M. Allen· 2 shared A. B. A. Laranjeira· 1 shared A. Z. Wang· 1 shared C. R. Zhang· 1 shared D. A. Fisher· 1 shared D. Fisher· 1 shared E. Krug· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

H. Celik

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2 papers

Recent·Most cited

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

T. Kong, A. B. A. Laranjeira, K. Yang, D. Fisher, L. Yu, A. Z. Wang, M. Ruzinova, J. Fowles, M. Allen, H. Celik, G. Challen, S. Huang, S. Oh

This study identifies DUSP6 as a driver of leukemic progression and resistance to JAK2 inhibition in MPNs, highlighting the DUSP6-RSK1 axis as a therapeutic target.

Nature Cancer · Dec 29, 2022Peer-reviewedCancer Biology

A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

H. Celik, E. Krug, C. R. Zhang, W. Han, N. Issa, W. K. Koh, H. Bjeije, O. Kukhar, M. Allen, T. Li, D. A. Fisher, J. Fowles, T. N. Wong, M. C. Stubbs, H. K. Koblish, , G. A. Challen

This paper introduces a humanized animal model using patient-derived xenografts to study myeloproliferative neoplasms and identify therapeutic vulnerabilities.

bioRxiv · Nov 12, 2020Cancer Biology