Author

M. Allen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Bioengineering· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

H. Celik· 2 shared J. Fowles· 2 shared Y. Liu· 2 shared A. B. A. Laranjeira· 1 shared A. E. E. Bruce· 1 shared A. G. Bell· 1 shared A. Jacobson· 1 shared A. W. Poole· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCancer Biology

H. Celik

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

CryoET reveals actin filaments within platelet microtubules

C. Tsuji, M. Bradshaw, M. Allen, M. L. Jackson, J. Mantell, U. Borucu, A. W. Poole, P. Verkade, I. Hers, D. M. Paul, M. Dodding

The paper uses cryoET to show cofilin-bound F-actin within platelet microtubules, revealing physiological actin-microtubule hybrids formed under mechanical stress.

bioRxiv · Nov 24, 2023Cell Biology

Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis

R. K. Komaravolu, P. Mehta-D'souza, T. Conner, M. Allen, J. Lumry, T. M. Griffin

This study investigates sex-specific effects of beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis, finding sexually dimorphic gene expression and metabolic changes.

bioRxiv · Aug 15, 2023Physiology

Analytical Comparability to Evaluate Impact of Manufacturing Changes of ARX788, an Anti-HER2 ADC in Late-Stage Clinical Development

M. P. Ramprasad, W. Yu, M. Pal, C. Chen, S. Paruchuri, L. Skidmore, N. Knudsen, M. Allen, Y. Buechler

The paper evaluates the impact of manufacturing changes on ARX788, an anti-HER2 ADC, using ICH Q5E guidelines and shows no adverse effect on product quality.

bioRxiv · Mar 27, 2023Cancer Biology

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

T. Kong, A. B. A. Laranjeira, K. Yang, D. Fisher, L. Yu, A. Z. Wang, M. Ruzinova, J. Fowles, M. Allen, H. Celik, G. Challen, S. Huang, S. Oh

This study identifies DUSP6 as a driver of leukemic progression and resistance to JAK2 inhibition in MPNs, highlighting the DUSP6-RSK1 axis as a therapeutic target.

Nature Cancer · Dec 29, 2022Peer-reviewedCancer Biology

Genomic evidence for inter-class host transition between abundant streamlined heterotrophs by a novel and ubiquitous marine Methylophage

H. H. Buchholz, L. M. Bolanos, A. G. Bell, M. L. Michelsen, M. Allen, B. Temperton

This paper isolates and characterizes a novel myophage infecting OM43 bacteria, revealing evidence of inter-class host transition between streamlined heterotrophs.

bioRxiv · Aug 24, 2021 · PreprintMicrobiology

The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

P. M. Willoughby, M. Allen, J. Yu, R. Korytnikov, T. Chen, Y. Liu, I. So, N. Macpherson, J. Mitchell, R. Fernandez-Gonzalez, A. E. E. Bruce

This study shows Rab25 coordinates cytokinetic bridge abscission and cortical actin density in zebrafish gastrula epithelium, affecting cell shape and tissue-scale forces during epiboly.

bioRxiv · Jan 29, 2021Cell Biology

A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

H. Celik, E. Krug, C. R. Zhang, W. Han, N. Issa, W. K. Koh, H. Bjeije, O. Kukhar, M. Allen, T. Li, D. A. Fisher, J. Fowles, T. N. Wong, M. C. Stubbs, H. K. Koblish, , G. A. Challen

This paper introduces a humanized animal model using patient-derived xenografts to study myeloproliferative neoplasms and identify therapeutic vulnerabilities.

bioRxiv · Nov 12, 2020Cancer Biology

Acoustogenetic Control of CAR T Cells via Focused Ultrasound

Y. WU, Y. Liu, Z. Huang, X. Wang, Z. Jin, J. Li, P. Limsakul, L. Zhu, M. Allen, Y. Pan, R. Bussell, A. Jacobson, T. Liu, S. Chien, Y. Wang

This paper develops an acoustogenetic method using focused ultrasound to control CAR T cells, enabling noninvasive activation to treat cancer with reduced off-tumor effects.

bioRxiv · Feb 18, 2020Bioengineering