Insulin-mediated suppression of fatty acid release predicts whole-body insulin resistance of glucose uptake and skeletal muscle insulin receptor activation
M. Schleh, B. Ryan, C. Ahn, A. Ludzki, D. Van Pelt, L. Pitchford, O. Chugh, A. T. Luker, K. E. Luker, D. Samovski, N. Abumrad, C. Burant, J. Horowitz
This study identifies reduced insulin-mediated suppression of fatty acid release and altered skeletal muscle lipid droplet characteristics as predictors of insulin resistance in adults with obesity.
bioRxiv · Feb 29, 2024 · PreprintPhysiology