Author

C. Barnes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:clustering· 3 Assay:whole-genome sequencing· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

A. Cho· 2 shared A. Gazumyan· 2 shared A. Sottoriva· 2 shared B. Werner· 2 shared C. Gaebler· 2 shared F. Muecksch· 2 shared F. Schmidt· 2 shared K. Huey-Tubman· 2 shared

Activity by Year

2016-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. Cho

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions

Z. Cheng, D. P. Ennis, B. Lu, H. B. Mirza, C. Sokota, B. Kaur, N. Singh, O. Le Saux, G. Russo, G. Giannone, L. A. Tookman, J. Krell, J. McDermott, C. Barnes, I. A. McNeish

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

bioRxiv · Mar 11, 2024 · PreprintCancer Biology

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

T. Heide, J. Househam, G. D. Cresswell, I. Spiteri, C. Lynn, C. Kimberley, M. Mossner, L. Zapata, C. Gabbutt, D. Ramazzotti, B. Chen, J. Fernandez-Mateos, C. James, F. Iorio, A. Berner, , A. Sottoriva

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

bioRxiv · Jul 14, 2021 · PreprintCancer Biology

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

F. Muecksch, Y. Weisblum, C. Barnes, F. Schmidt, D. Schaefer-Babajew, J. Lorenzi, A. Flyak, A. DeLaitsch, K. Huey-Tubman, S. Hou, C. Schiffer, C. Gaebler, Z. Wang, J. Da Silva, D. Poston, , P. Bieniasz

This study examines how somatic mutations in SARS-CoV-2 antibodies affect their neutralization potency, breadth, and resistance to escape mutations across six antibody lineages.

bioRxiv · Mar 7, 2021 · PreprintMicrobiology

Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals

D. F. Robbiani, C. Gaebler, F. Muecksch, J. Cetrulo Lorenzi, Z. Wang, A. Cho, M. Agudelo, C. Barnes, S. Finkin, T. Hagglof, T. Oliveira, C. Viant, A. Hurley, K. Millard, R. Kost, , Nuss

The paper analyzes antibody responses in convalescent individuals, finding low neutralizing titers but rare potent RBD-specific antibodies with broad antiviral potential.

bioRxiv · May 13, 2020Immunology

Quantification of subclonal selection in cancer from bulk sequencing data

M. J. Williams, B. Werner, C. Curtis, C. Barnes, A. Sottoriva, T. A. Graham

This study quantifies subclonal selection in cancer using bulk sequencing data to determine mutation rates, selective advantages, and subclone emergence times in gastric and lung cancers.

bioRxiv · Dec 24, 2016Cancer Biology