ImmunologybioRxiv
A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two
C. Tan, R. Hiwa, J. L. Mueller…·J. Zikherman
This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.
DOI 10.1038/s41590-020-0765-7