J. J. Chou

The study identifies direct transmembrane domain interactions as critical for gamma-chain family receptor sharing and activation.

The paper determines the NMR structure of the SARS-CoV-2 spike protein transmembrane domain, revealing a trimeric hydrophobic zipper that stabilizes the trimer and can be disrupted by specific mutations.

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

This paper describes a method to assemble multi-specific antibodies using DNA-mediated assembly, showing efficacy in tumor cell cytotoxicity and xenograft suppression.