Q. Fu

A high resolution model of the grapevine leaf morphospace predicts synthetic leaves

The paper develops a high-resolution morphospace model of grapevine leaves to predict synthetic leaves and improve classification accuracy.

Paradigm shift in biomarker translation: a pipeline to generate clinical grade biomarker candidates from DIA-MS discovery

This paper introduces TEAQ, a software tool that selects clinical-grade biomarker candidates from DIA-MS data by evaluating protein quantification metrics in a discovery cohort.

Protein disulfide isomerase disassembles stress granules and blocks cytoplasmic aggregation of TDP-43 in ALS

This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.

Characterization of Tumor-Associated Endothelial Cells and the Development of a Prognostic Model in Pancreatic Ductal Adenocarcinoma

This study identifies a specific subset of tumor-associated endothelial cells in PDAC and develops a prognostic model, TaEMS, to predict patient outcomes based on immune and cellular pathway profiles.

Large-scale analysis of the N-terminal regulatory elements of the kinase domain in plant receptor-like kinase family

The paper analyzes NRE sequences in RLKs and RLCKs from 528 plants to uncover structural-functional relationships and phosphorylation motifs, revealing their role in kinase regulation.

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

Plant Virus Database: a resource for exploring the diversity of plant viruses and their interactions with hosts

The paper builds a comprehensive Plant Virus Database (PVD) containing 3,206 virus species and 9,604 host interactions, revealing significant virome differences between plant groups and regions.

CAR modulates plasma membrane nano-organization and immune signaling downstream of RALF1-FERONIA signaling pathway

This study shows that the FER-CAR module regulates plasma membrane nano-organization and immune signaling through a feedback loop during RALF1 signaling.

A high throughput bispecific antibody discovery pipeline

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.

A trimeric hydrophobic zipper mediates the intramembrane assembly of SARS-CoV-2 spike

The paper determines the NMR structure of the SARS-CoV-2 spike protein transmembrane domain, revealing a trimeric hydrophobic zipper that stabilizes the trimer and can be disrupted by specific mutations.

Standardized workflow for precise mid- and high-throughput proteomics of blood biofluids

The paper develops a standardized proteomics workflow for high- and mid-throughput analysis of blood biofluids, showing reliable protein detection across different matrices.

Is there a need for preoperative α-blocker in patients missed preoperative diagnosis of extra-adrenal retroperitoneal paraganglioma undergoing paraganglioma resection? A retrospective study of 167 cases at a single center

This study evaluates the impact of preoperative α-blocker use on outcomes in extra-adrenal retroperitoneal paraganglioma surgeries, finding no significant differences in postoperative complications.

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes

This study examines the temporal metabolic and transcriptomic changes in islets and liver of mice on high-fat diet, revealing dynamic pathophysiology and interorgan crosstalk in diabetes.

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

The evolutionary history of Neandertal and Denisovan Y chromosomes

The paper analyzes ancient Y chromosomes from Denisovans and Neandertals, finding they split from a shared lineage around 700 kya, with Neandertal Y chromosomes diverging from modern humans around 370 kya.

Aerodynamic Characteristics and RNA Concentration of SARS-CoV-2 Aerosol in Wuhan Hospitals during COVID-19 Outbreak

The paper measures SARS-CoV-2 RNA concentration in aerosols from different areas of Wuhan hospitals during the COVID-19 outbreak and finds that aerosol transmission is possible under certain conditions.

Injectable therapeutic organoids using sacrificial hydrogels

This paper introduces a method using sacrificial hydrogels to produce reproducible multicellular organoid structures for cell therapy, demonstrating their ability to form functional vasculature in vivo.

AVDM: Angular Velocity Decoding Model Accounting for Visually Guided Flight Behaviours of the Bee

The paper introduces an angular velocity decoding model for honeybee flight behaviors, showing independence from spatial frequency and contrast, and validating it through simulations and behavioral experiments.

Genomic approaches reveal an endemic sub-population of gray wolves in Southern China

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

Penaeidins are a novel family of antiviral effectors against WSSV in shrimp

This study identifies penaeidins as antiviral effectors in shrimp that bind WSSV virions, inhibit viral entry, and are regulated by Toll and IMD pathways.

Mesenchymal stem cells protect retinal ganglion cells from degeneration via mitochondrial donation

This study shows that mesenchymal stem cells (MSCs) protect retinal ganglion cells (RGCs) from degeneration by donating mitochondria, reducing inflammation, and preserving retinal function in a mouse model.

RNAi screening identifies a new Toll from shrimp that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides

Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to arctic sled dogs

Resting heart rate and psychopathy: Findings from the Add Health Survey

This study examines the relationship between resting heart rate and psychopathic traits using a large national sample, finding no significant association after controlling for age, sex, and race.