Author

T. Cai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 3 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Organism:human· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:deep learning· 2

Frequent Co-Authors

A. Margariti· 2 shared L. Zeng· 2 shared X. Bai· 2 shared Y. Tao· 2 shared Y. Zhao· 2 shared Z. Chen· 2 shared A. Angbohang· 1 shared A. L. Notkins· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

A. Margariti

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

A novel nested gene Aff3ir participates in vascular remodelling by enhancing endothelial cell differentiation in mice

Y. Zhao, M. Ehteramyan, Y. Li, X. Bai, L. Huang, Y. Gao, A. Angbohang, X. Yang, S. Lynham, A. Margariti, A. Shah, Y. Tao, T. Cai, T. Li, M. Zhang, L. Zeng

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.

bioRxiv · Dec 9, 2023 · PreprintCell Biology

Human TUBA1B short open reading frame product regulates cancer cell growth via importin-β

Y. Tao, X. Bai, Y. Zhou, Y. Zhao, L. Yang, S. Zhang, H. Liu, X. Huang, E. Schneider, A. Zampetaki, A. Margariti, M. Giacca, J. N. Arnold, L. Zeng, T. Cai

This study identifies TUBA1B-sORF1, a novel protein from the TUBA1B gene, which promotes cancer cell growth by facilitating nuclear translocation of β-catenin.

bioRxiv · Aug 26, 2023 · PreprintCancer Biology

Structural basis of γ-chain family receptor sharing at the membrane level

T. Cai, R. Lenoir Capello, X. Pi, H. Wu, J. J. Chou

The study identifies direct transmembrane domain interactions as critical for gamma-chain family receptor sharing and activation.

bioRxiv · May 5, 2023 · PreprintImmunology

Degrading intestinal DAF-2 nearly doubles Caenorhabditis elegans lifespan without affecting development or reproduction

Y.-P. Zhang, W.-H. Zhang, P. Zhang, Q. Li, Y. Sun, J.-W. Wang, S.-B. O. Zhang, T. Cai, C. Zhan, M.-Q. Dong

This study shows that reducing DAF-2 in the intestine of C. elegans nearly doubles lifespan without affecting development or reproduction.

bioRxiv · Jul 31, 2021 · PreprintCell Biology

Compensating complete loss of signal recognition particle during co-translational protein targeting by the translation speed and accuracy

L. Zhao, G. Fu, Y. Cui, Z. Xu, T. Cai, D. Zhang

The paper identifies a suppressor mutation that compensates for SRP loss by slowing translation and reducing fidelity, allowing correct protein targeting in E. coli.

bioRxiv · Jan 6, 2021Microbiology

Potentiating CD8+ T cell antitumor activity by targeting the PCSK9/LDLR axis

J. Yuan, T. Cai, X. Zheng, Y. Ren, J. Qi, H. Lin, X. Lu, Z. Chen, H. Chen, M. Liu, S. He, S. Feng, Y. Wu, Q. Chen, Z. Zhang, , W. Yang

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

bioRxiv · Dec 3, 2020 · PreprintImmunology

Machine Learning-Based Protein Microarray Digital Assay Analysis

Y. Song, J. Zhao, T. Cai, S.-H. Su, E. Sandford, C. Flora, B. H. Singer, M. Ghosh, S. W. Choi, M. Tewari, K. Kurabayashi

The paper develops a microfluidic digital immunoassay using machine learning for rapid, multiplexed biomarker detection in clinical samples.

bioRxiv · Aug 4, 2020 · PreprintBioengineering

The Nucleocapsid Protein of SARS-CoV-2 Abolished Pluripotency in Human Induced Pluripotent Stem Cells

Z. Lin, Z. Wu, J. Mai, L. Zhou, Y. Qian, T. Cai, Z. Chen, P. Wang, B. Lin

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

bioRxiv · Mar 26, 2020 · PreprintCell Biology

Determination of secretory granule maturation times in pancreatic islet beta-cells by serial block face scanning electron microscopy

A. Rao, E. L. McBride, G. Zhang, T. Cai, A. L. Notkins, M. A. Aronova, R. D. Leapman

The paper uses SBEM to determine secretory granule maturation times in mouse pancreatic beta-cells, finding immature granules remain in their state for about 2 hours before transforming.

bioRxiv · Dec 5, 2019Biophysics

An atlas of infiltrated B-lymphocytes in breast cancer revealed by paired single-cell RNA-sequencing and antigen receptor profiling

q. hu, y. hong, p. qi, g. lu, x. mai, s. xu, x. he, y. guo, l. gao, z. jing, j. wang, t. cai, y. zhang

This study identifies a comprehensive atlas of B-lymphocytes in triple-negative breast cancer using single-cell RNA-sequencing and antigen receptor profiling, revealing their mature characteristics and prognostic significance.

bioRxiv · Jul 15, 2019Immunology