J. J. Gokey

Inhibiting hypoxia-inducible-factor 2 (HIF2) promotes functional lung alveolar epithelial repair following recurrent injury.

This study shows that Yap/Taz in AT2 cells are essential for alveolar regeneration and preventing fibrosis after lung injury.

This study identifies intrinsic AT2 progenitor dysfunction and p53 pathway dysregulation as novel mechanisms driving pulmonary fibrosis in Hermansky-Pudlak syndrome.

This study identifies myeloid cell-derived IL1β as a key driver of pulmonary vascular remodeling in HFpEF using a murine model and multi-omics approaches.

This study develops a mouse model of repetitive sulfur dioxide exposure that mimics post-deployment respiratory syndrome features, identifying oxidative stress as a mediator of pulmonary vascular disease.

The paper compares single-cell transcriptomic profiles of human PCLS after five days of culture to freshly isolated lung tissue, finding changes in endothelial and alveolar epithelial cell programs but stable immune cell profiles.