T. S. Blackwell

Inhibiting hypoxia-inducible-factor 2 (HIF2) promotes functional lung alveolar epithelial repair following recurrent injury.

This study shows that Yap/Taz in AT2 cells are essential for alveolar regeneration and preventing fibrosis after lung injury.

This study develops a mouse model of repetitive sulfur dioxide exposure that mimics post-deployment respiratory syndrome features, identifying oxidative stress as a mediator of pulmonary vascular disease.

This study shows that β1-containing integrins are essential for alveolar repair after injury, as their absence leads to emphysema and impaired differentiation of AT2 cells into mature type 1 alveolar epithelial cells.

This study identifies a unique epithelial cell population in human distal airways and shows its reduction in COPD, linked to IFN-gamma signaling.

The paper identifies secretory cells as the main source of pIgR in airways and shows reduced pIgR protein expression, not cell numbers, contributes to SIgA loss in COPD.