Author

J. L. Hukelmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

A. I. Lamond· 3 shared D. A. Cantrell· 3 shared A. J. Brenes· 2 shared L. Spinelli· 2 shared L. V. Sinclair· 2 shared A. Brenes· 1 shared A. Casey· 1 shared A. I. I. Lamond· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

A. I. Lamond

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Author profile →

4 papers

Recent·Most cited

The Immunological Proteome Resource

A. J. Brenes, J. L. Hukelmann, L. Spinelli, A. J. M. Howden, J. M. Marchingo, L. V. Sinclair, C. Rollings, O. J. James, I. R. Phair, S. P. Matthews, S. H. Ross, S. C. Arthur, M. Swamy, D. K. Finlay, A. I. I. Lamond, D. A. Cantrell

The paper introduces ImmPRes, a proteomic resource integrating mass-spectrometry data from murine hematopoietic cells to study immune activation and signaling.

bioRxiv · Aug 29, 2022Immunology

Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response

D. G. Ryan, E. V. Knatko, A. Casey, J. L. Hukelmann, A. J. Brenes, S. Dayalan Naidu, M. Higgins, L. Tronci, E. Nikitopoulou, L. A. O'Neill, A. I. Lamond, A. Y. Abramov, D. A. Cantrell, M. P. Murphy, A. T. Dinkova-Kostova

This study shows Nrf2 regulates macrophage metabolism, redox balance, and inflammatory responses, with 4-OI modulating these effects through Nrf2.

bioRxiv · Aug 13, 2021 · PreprintImmunology

Antigen receptor control of methionine metabolism in T cells

L. V. Sinclair, A. J. Howden, A. J. Brenes-Murillo, L. Spinelli, J. L. Hukelmann, A. N. Macintyre, X. Liu, S. Thomson, P. M. Taylor, J. C. Rathmell, J. W. Locasale, A. I. Lamond, D. A. Cantrell

This study shows antigen receptor engagement controls methionine cycle flux and methyl donor availability for RNA and histone methylation in T cells.

bioRxiv · Dec 18, 2018Immunology

Optimising multi-batch TMT analysis to mitigate inflation of missing values, false positives and diminished inter batch accuracy

A. Brenes, J. L. Hukelmann, D. Bensaddek, A. I. Lamond

The paper evaluates the impact of integrating multiple TMT batches in proteomic analysis and proposes solutions to reduce missing values, false positives, and inter-batch accuracy issues.

bioRxiv · Dec 16, 2018 · PreprintBiochemistry