Author

M. P. Murphy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Cancer Biology· 1 Evolutionary Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:bulk RNA-seq· 6 Research Focus:cell type annotation· 5 Assay:proteomics· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Approach:statistical model· 3

Frequent Co-Authors

D. G. Ryan· 2 shared E. Nikitopoulou· 2 shared H. A. Prag· 2 shared J. L. Miljkovic· 2 shared A. Cardenas· 1 shared A. Casey· 1 shared A. Choksey· 1 shared A. Garcia-Gimenez· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

D. G. Ryan

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition

A. Garcia-Gimenez, J. E. Ditcham, D. M. A. Azazi, E. Meduri, R. Asby, N. Sakakini, C. K. Lopez, N. Narayan, T. Beinortas, J. Bagri, S. Agrawal Singh, G. Giotopoulos, M. P. Murphy, S. J. Horton, B. Huntly, S. E. Richardson

This study identifies CREBBP mutations as a targetable vulnerability in B-ALL, showing that CREBBP inhibition sensitizes these cells to Venetoclax-induced ferroptosis.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Naked mole rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

C. G. Faulkes, T. R. Eykyn, J. L. Miljkovic, R. L. Charles, H. A. Prag, N. Patel, D. Hart, M. P. Murphy, N. C. Bennett, D. Aksentijevic

The paper identifies metabolic and genetic adaptations in naked mole-rats that confer resistance to cardiovascular disease and hypoxia.

bioRxiv · May 19, 2023Physiology

AICAR prevents doxorubicin-induced heart failure in rats by ameliorating cardiac atrophy and improving fatty acid oxidation

A. Choksey, B. D. Thackray, V. Ball, L. Hong Tuan Ha, E. Sharma, B. W. Kennedy, R. D. Carter, J. Broxholme, M. P. Murphy, L. C. Heather, D. J. Tyler, K. N. Timm

This study shows AICAR prevents doxorubicin-induced heart failure in rats by improving cardiac function, mitochondrial fatty acid oxidation, and preventing myocardial atrophy.

bioRxiv · Aug 17, 2022 · PreprintBiochemistry

Origin, Prospective Identification, and Function of Circulating Endothelial Colony Forming Cells in Mouse and Human

Y. Lin, K. Banno, C.-H. Gil, J. Myslinski, T. Hato, W. C. Shelley, H. Gao, X. Xuei, Y. Liu, D. P. Basile, M. Yoshimoto, N. Prasain, S. P. Tarnawsky, R. H. Adams, K. Naruse, , M. C. Yoder

This study identifies the origin and function of circulating endothelial colony forming cells (C-ECFCs) in mice and humans, showing they arise from tissue-resident ECFCs and have vasculogenic potential.

bioRxiv · Jul 31, 2022 · PreprintCell Biology

A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

G. Sturm, A. S. Monzel, K. R. Karan, J. Michelson, S. A. Ware, A. Cardenas, J. Lin, C. Bris, B. Santhanam, M. P. Murphy, M. E. Levine, S. Horvath, D. W. Belsky, S. Wang, V. Procaccio, , M. Picard

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

bioRxiv · Nov 12, 2021Cell Biology

Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response

D. G. Ryan, E. V. Knatko, A. Casey, J. L. Hukelmann, A. J. Brenes, S. Dayalan Naidu, M. Higgins, L. Tronci, E. Nikitopoulou, L. A. O'Neill, A. I. Lamond, A. Y. Abramov, D. A. Cantrell, M. P. Murphy, A. T. Dinkova-Kostova

This study shows Nrf2 regulates macrophage metabolism, redox balance, and inflammatory responses, with 4-OI modulating these effects through Nrf2.

bioRxiv · Aug 13, 2021 · PreprintImmunology

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

D. G. Ryan, M. Yang, H. A. Prag, G. R. Blanco, E. Nikitopoulou, M. Segarra-Mondejar, C. A. Powell, T. Young, N. Burger, J. L. Miljkovic, M. Minczuk, M. P. Murphy, A. Von Kriegsheim, C. Frezza

This study investigates the effects of TCA cycle inhibition on redox and amino acid metabolism, revealing ATF4-dependent metabolic rewiring and distinct responses between FH and SDH inhibition.

bioRxiv · Jul 27, 2021Biochemistry

Convergent evolution of conserved mitochondrial pathways underlies repeated adaptation to extreme environments

R. Greenway, N. Barts, C. Henpita, A. P. Brown, L. Arias-Rodriguez, C. M. Rodriguez Pena, S. Arndt, G. Y. Lau, M. P. Murphy, L. Wu, D. Lin, J. H. Shaw, J. L. Kelley, M. Tobler

This study identifies convergent genetic and physiological adaptations in multiple fish lineages that enable tolerance to hydrogen sulfide, showing that conserved mitochondrial pathways are repeatedly modified for H2S resistance.

bioRxiv · Feb 24, 2020Evolutionary Biology