J. M. Morrisey

This study shows that knocking out isocitrate dehydrogenase (IDH) in Plasmodium falciparum parasites arrests gametocyte development, similar to aconitase knockout, and suggests IDH as a potential target for malaria transmission control.

The paper identifies 122 putative mitochondrial proteins in Plasmodium falciparum using proximity biotinylation and mass spectrometry, with four confirmed mitochondrial proteins of unknown function.

This paper shows that reducing erythrocyte membrane cholesterol with MβCD causes rapid expulsion of Plasmodium falciparum trophozoites, and antimalarials targeting PfATP4 or PfNCR1 inhibit this process.

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

The paper screens compounds to identify those disrupting Plasmodium falciparum plasma membrane lipid homeostasis, finding some act independently of Na+ homeostasis and target PfNCR1.

This paper shows that PfNDH2 in Plasmodium falciparum is not essential and that purported NDH2 inhibitors actually target the cytochrome bc1 complex.