M. W. Mather

This study shows that knocking out isocitrate dehydrogenase (IDH) in Plasmodium falciparum parasites arrests gametocyte development, similar to aconitase knockout, and suggests IDH as a potential target for malaria transmission control.

The paper identifies 122 putative mitochondrial proteins in Plasmodium falciparum using proximity biotinylation and mass spectrometry, with four confirmed mitochondrial proteins of unknown function.

This study investigates the effects of conditional knockdown of mitochondrial ribosomal proteins RSM22 and L23 in Plasmodium falciparum, revealing distinct transcriptional responses and metabolic defects leading to parasite death.

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

This study shows that disrupting the mitochondrial ribosome in Plasmodium falciparum makes the parasite more sensitive to drugs targeting mitochondrial functions.

This paper shows that PfNDH2 in Plasmodium falciparum is not essential and that purported NDH2 inhibitors actually target the cytochrome bc1 complex.