S. Bhatnagar

Hydrocarbon-degrading microbial populations in permanently cold deep-sea sediments in the NW Atlantic

The paper examines hydrocarbon-degrading microbial responses in deep-sea sediments to naphtha amendment, finding that seep sediments remove BTEX compounds more effectively than non-seep sediments.

Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite

This study identifies PfPK2 as a critical kinase for malaria parasite invasion of erythrocytes by regulating microneme protein release, cGMP, and calcium signaling.

Synaptotagmin-9 and Tomosyn-1 molecular complex regulates Stx1A SNAREs to inhibit insulin secretion from pancreatic beta-cells

This study shows that synaptotagmin-9 inhibits insulin secretion by forming a complex with Tomosyn-1 and Stx1A, reducing SNARE complex formation in pancreatic beta-cells.

Ancestral SARS-CoV-2 driven antibody repertoire diversity in an unvaccinated individual correlates with expanded neutralization breadth

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

Environmental selection influences the microbiome of subsurface petroleum reservoirs

This study analyzes microbial communities in oil reservoirs, finding a functional core but no taxonomic core, and highlights metabolic redundancy and potential for predicting responses to environmental changes.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

Geological processes mediate a subsurface microbial loop in the deep biosphere

The paper investigates a subsurface microbial loop mediated by geological processes, showing thermophilic endospores migrate from deep oil reservoirs to the seabed and re-enter the geosphere through sedimentation.

Dramatic consequences of reducing erythrocyte membrane cholesterol on Plasmodium falciparum

This paper shows that reducing erythrocyte membrane cholesterol with MβCD causes rapid expulsion of Plasmodium falciparum trophozoites, and antimalarials targeting PfATP4 or PfNCR1 inhibit this process.

An integrative approach to mosquito dynamics reveals differences in people's everyday experiences of mosquitoes

The paper uses an integrative approach to study mosquito dynamics in urban areas, finding differences in people's experiences with mosquitoes despite no difference in abundance.

Implicating Gene and Cell Networks Responsible for Differential COVID-19 Host Responses via an Interactive Single Cell Web Portal

The paper creates a web portal to compare single-cell transcriptome data from COVID-19 and control samples, identifying gene and cell network hypotheses related to differential host responses.

Microbial community dynamics and coexistence in a sulfide-driven phototrophic bloom

The paper studies microbial community dynamics in a sulfide-driven phototrophic bloom, identifying ecological niches and sulfur cycling involving phototrophic bacteria and viruses.

Diverse chemical compounds target Plasmodium falciparum plasma membrane lipid homeostasis

The paper screens compounds to identify those disrupting Plasmodium falciparum plasma membrane lipid homeostasis, finding some act independently of Na+ homeostasis and target PfNCR1.

Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis

This study identifies PfNCR1 as a critical protein for Plasmodium falciparum membrane homeostasis and shows it is a potential druggable target for antimalarial drugs.

Cell-intrinsic genetic regulation of peripheral memory-phenotype T cell frequencies

The paper shows memory T cell frequencies are genetically regulated and stable over time, while recently activated cells are influenced by environmental factors.

Transient exposure to oxygen or nitrate reveals ecophysiology of fermentative and sulfate-reducing benthic microbial populations

The paper investigates microbial ecophysiology in marine sediments by exposing cultures to oxygen or nitrate, revealing trophic networks and a novel fermentative organism.