Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production
E. N. Perrault, J. M. Shireman, E. S. Ali, I. Preddy, P. Lin, C. Park, L. Tomes, A. J. Zolp, S. Budhiraja, S. Baisiwala, C. D. James, I. Ben-Sahra, S. Pott, A. Basu, A. U. Ahmed
This study identifies RRM2 as a driver of TMZ resistance in GBM by modulating dNTP production, showing RRM2 inhibition enhances TMZ efficacy in vivo.
bioRxiv · Nov 23, 2021 · PreprintCancer Biology