J. R. Brewer

This study shows IL-10 limits inflammation by restricting sphingolipid metabolism through fatty acid desaturation, with metabolic correction reducing inflammation in IL-10-deficient macrophages.

This study uses 3D-STED microscopy to reveal the 3D nanostructure of desmosomes in mouse and human epidermis, showing ring-like structures and changes in desmoplakin distribution across skin layers.

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

This study shows that a compromised epidermal barrier increases energy expenditure, food intake, and white adipose tissue browning while preventing diet-induced obesity.