Author

E. Kaffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

J. R. Brewer· 2 shared R. A. Flavell· 2 shared Y. Kluger· 2 shared A. G. York· 1 shared A. Han· 1 shared A. Iwasaki· 1 shared B. Israelow· 1 shared C. B. Wilen· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

J. R. Brewer

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Author profile →

3 papers

Recent·Most cited

IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation

A. G. York, M. H. Skadow, R. G. Qu, J. Oh, W. K. Mowel, J. R. Brewer, E. Kaffe, K. J. Williams, Y. Kluger, J. M. Crawford, S. M. Smale, S. J. Bensinger, R. A. Flavell

This study shows IL-10 limits inflammation by restricting sphingolipid metabolism through fatty acid desaturation, with metabolic correction reducing inflammation in IL-10-deficient macrophages.

bioRxiv · May 7, 2023 · PreprintImmunology

Inflammasome activation in infected macrophages drives COVID-19 pathology

E. Sefik, R. Qu, C. Junqueira, E. Kaffe, H. Mirza, J. Zhao, J. R. Brewer, A. Han, H. R. Steach, B. Israelow, H. N. Blackburn, S. Velazquez, Y. G. Chen, S. Halene, A. Iwasaki, , R. A. Flavell

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

bioRxiv · Sep 27, 2021Immunology

Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis

I. Ninou, I. Sevastou, C. Magkrioti, E. Kaffe, G. Stamatakis, S. Thivaios, G. Panayotou, J. Aoki, G. Kollias, V. Aidinis

The paper shows that deleting Autotaxin in CD11b+ cells reduces experimental autoimmune encephalomyelitis severity, indicating a pathogenic role for the ATX/LPA axis in neuroinflammation.

bioRxiv · Nov 20, 2019Immunology