The NK receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
S. Sen Santara, A. C. Crespo, D.-J. Lee, J. Hu, Y. Zhang, S. Chowdhury, K. F. Meza-Sosa, M. Rowe, A. McClelland, H. Wu, C. Junqueira, J. Lieberman
This study identifies ecto-calreticulin as the ligand for the NKp46 receptor, showing it mediates NK cell recognition and killing of ER-stressed cells and tumors.
bioRxiv · Oct 31, 2021Immunology