A. Han

A nociceptive amygdala-striatal pathway for chronic pain aversion

This study identifies a BLAnoci ensemble in the basolateral amygdala that mediates both acute and chronic pain behavior through a novel amygdala-striatal circuit involving the nucleus accumbens shell.

A microfluidic model of colonocyte-microbiota interaction mimicking the colorectal cancer microenvironment

The paper develops a microfluidic model to study interactions between colonocytes, microbiota, and Fusobacterium nucleatum in a colorectal cancer microenvironment, showing altered gene expression and microbiota composition.

Individuals lack the capacity to accurately detect emotional piloerection

The paper shows humans cannot accurately detect their own piloerection events, with self-reports often mismatching observable occurrences.

Analysis of the Drosophila Ajuba LIM protein defines functions for distinct LIM domains

The paper investigates the distinct functions of Drosophila Ajuba LIM protein's LIM domains in regulating Hippo signaling and cell shape through in vivo and in vitro experiments.

Deep Learning-based Microbubble Localization for Ultrasound Localization Microscopy

This study develops a deep learning method for microbubble localization in ultrasound imaging, showing improved accuracy and performance in vivo.

Shiitake mycelium fermentation improves digestibility, nutritional value, flavor and functionality of plant proteins

This study shows that fermenting pea and rice protein with shiitake mycelium improves digestibility, nutritional value, and flavor, making it a better meat substitute.

Inflammasome activation in infected macrophages drives COVID-19 pathology

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

Sex differences in learning from exploration

This study identifies sex differences in exploration patterns during value-based decision making in mice, showing males explore more but get stuck, while females explore less but learn faster.

Sub-second heat inactivation of coronavirus

This paper develops a system to measure sub-second heat inactivation of coronavirus and identifies conditions achieving >5 Log10 viral titer reduction.

The functional and phenotypic diversity of single T-cell infiltrates in human colorectal cancer as correlated with clinical outcome

The paper analyzes T-cell infiltration in colorectal cancer, identifying prognostic and non-prognostic T cell subtypes and their clinical implications.

Genotypic diversity and dynamic nomenclature of Parechovirus A

The paper improves the genotyping system for Parechovirus A by proposing a dynamic nomenclature based on amino-acid level phylogenetic analysis and clustering.

Conserved anti-inflammatory effects and sensing of butyrate in zebrafish

The paper shows that butyrate, a short-chain fatty acid, has anti-inflammatory effects in zebrafish by reducing neutrophil and M1 macrophage recruitment to wounds, and identifies a conserved receptor for butyrate sensing in fish.

Crowding tunes 3D collagen fibrils and reveals matrix regulation of cancer cell morphogenesis

This study shows that tuning 3D collagen fibril architecture using PEG affects cancer cell morphology and migration strategies.