Author

J. R. Garneau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Organism:C. elegans· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

L.-C. Fortier· 4 shared O. Soutourina· 3 shared M.-M. Allen· 2 shared A. A. Umansky· 1 shared A. Berard· 1 shared A. Boutserin· 1 shared A. Hamiot· 1 shared A. L. M. Royer· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersMicrobiology

L.-C. Fortier

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7 papers

Recent·Most cited

Dual RNA-seq study of the dynamics of coding and non-coding RNAs expression during Clostridioides difficile infection in a mouse model

V. Kreis, C. Toffano-Nioche, C. Deneve-Larrazet, J.-C. Marvaud, J. R. Garneau, F. Dumont, E. van Dijk, Y. Jaszczyszyn, A. Boutserin, F. D'Angelo, D. Gautheret, I. Kansau, C. Janoir, O. Soutourina

This paper uses dual RNA-seq to study coding and non-coding RNA expression dynamics in C. difficile infection in mice, identifying new ncRNA genes and host miRNAs associated with infection.

bioRxiv · Jun 28, 2024 · PreprintMicrobiology

Novel phages of Pseudomonas syringae unveil numerous potential auxiliary metabolic genes

C. Feltin, J. R. Garneau, C. E. Morris, A. Berard, C. Torres-Barcelo

This study isolates and characterizes 25 new phages infecting Pseudomonas syringae, revealing genetic diversity and potential auxiliary metabolic genes.

bioRxiv · May 7, 2024Microbiology

Molecular and evolutionary basis of O-antigenic polysaccharide driven phage sensitivity in environmental pseudomonads

J. Vacheron, C. M. Heiman, J. R. Garneau, P. Kupferschmied, R. deJonge, D. Garrido-Sanz, C. Keel

This study identifies the O-antigenic polysaccharide as a receptor for phage {Phi}GP100 in Pseudomonas protegens CHA0, revealing its role in phage sensitivity and genomic plasticity of the OBC3 gene cluster.

bioRxiv · May 15, 2023Microbiology

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

Q. Dong, H. Lin, M.-M. Allen, J. R. Garneau, J. K. Sia, R. C. Smith, F. Haro, T. McMillen, R. L. Pope, C. Metcalfe, V. Burgo, C. Woodson, N. Dylla, C. Kohout, A. Sundararajan, , E. G. Pamer

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

bioRxiv · Jan 12, 2023Microbiology

The Clostridioides difficile S-Layer Protein A (SlpA) serves as a general phage receptor

A. L. M. Royer, A. A. Umansky, M.-M. Allen, J. R. Garneau, M. O. Bedoya, J. A. Kirk, G. Govoni, R. P. Fagan, O. Soutourina, L.-C. Fortier

This paper demonstrates that SlpA is a common receptor for multiple C. difficile phages, enabling the rational design of phage cocktails.

bioRxiv · Sep 19, 2022Microbiology

Type I toxin-antitoxin systems contribute to mobile genetic elements maintenance in Clostridioides difficile and can be used as a counter-selectable marker for chromosomal manipulation

J. Peltier, A. Hamiot, J. R. Garneau, P. Boudry, A. Maikova, L.-C. Fortier, B. Dupuy, O. Soutourina

The paper characterizes type I toxin-antitoxin systems in C. difficile prophages, showing their role in prophage stability and introducing them as counter-selectable markers for chromosomal manipulation.

bioRxiv · Mar 4, 2020Microbiology

PhageTerm: a Fast and User-friendly Software to Determine Bacteriophage Termini and Packaging Mode using randomly fragmented NGS data

J. R. Garneau, F. Depardieu, L.-C. Fortier, D. Bikard, M. Monot

PhageTerm determines bacteriophage DNA termini and packaging modes using NGS data, validated on known phages and new isolates.

bioRxiv · Feb 16, 2017Microbiology