Author

R. C. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Microbiology· 6 Ecology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 13 Research Focus:host-pathogen & immune response· 10 Research Focus:cell type annotation· 8 Research Focus:differential expression· 5 Organism:mouse· 5 Approach:statistical model· 5 Research Focus:cell signaling & trafficking· 4 Assay:bulk RNA-seq· 3

Frequent Co-Authors

H. Kwon· 7 shared A. Adegoke· 3 shared D. R. Hall· 3 shared R. A. Reynolds· 3 shared S. Karim· 3 shared A. Sundararajan· 2 shared C. Woodson· 2 shared E. G. Pamer· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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7 shared papersImmunology

H. Kwon

Mutual co-authors in cluster

Author profile →

16 papers

Recent·Most cited

Mosquito immune cells enhance dengue and Zika virus dissemination in Aedes aegypti

D. R. Hall, R. M. Johnson, H. Kwon, Z. Ferdous, S. V. Laredo-Tiscareno, B. J. Blitvich, D. E. Brackney, R. C. Smith

This study shows mosquito immune cells help spread dengue and Zika viruses in Aedes aegypti, supporting a 'trojan horse' model of virus dissemination.

bioRxiv · Apr 3, 2024 · PreprintMicrobiology

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution

Z. J. Zhang, C. G. Cole, M. Coyne, H. Lin, N. Dylla, R. C. Smith, E. Waligurski, R. Ramaswamy, C. Woodson, V. Burgo, J. Little, D. Moran, A. Rose, M. McMillin, E. Mcspadden, , L. E. Comstock

The paper characterizes a large collection of Bacteroidales isolates from the human gut, revealing genomic and metabolomic diversity and horizontal gene transfer across species.

bioRxiv · Mar 8, 2024Microbiology

Tick Innate Immune Responses to Hematophagy and Ehrlichia Infection at Single-Cell Resolution

A. Adegoke, J. M. Ribeiro, R. C. Smith, S. Karim

This study uses single-cell RNA sequencing to analyze hemocyte populations in ticks during hematophagy and Ehrlichia infection, identifying distinct subpopulations and their gene expression changes.

bioRxiv · Oct 2, 2023 · PreprintImmunology

Ehrlichia chaffeensis co-opts phagocytic hemocytes for systemic dissemination in the Lone Star tick, Amblyomma americanum

A. Adegoke, J. Hanson, R. C. Smith, S. Karim

This study shows granulocytes in the Lone Star tick play dual roles in controlling and facilitating Ehrlichia chaffeensis infection.

bioRxiv · Aug 17, 2023 · PreprintImmunology

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

Q. Dong, H. Lin, M.-M. Allen, J. R. Garneau, J. K. Sia, R. C. Smith, F. Haro, T. McMillen, R. L. Pope, C. Metcalfe, V. Burgo, C. Woodson, N. Dylla, C. Kohout, A. Sundararajan, , E. G. Pamer

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

bioRxiv · Jan 12, 2023Microbiology

Rickettsia parkeri Hijacks Tick Hemocytes to Manipulate Cellular and Humoral Transcriptional Responses

A. Adegoke, J. M. C. Ribeiro, S. Brown, R. C. Smith, S. Karim

This study identifies five hemocyte populations in ticks and shows Rickettsia parkeri infects phagocytic hemocytes, altering immune gene expression and phagocytosis.

bioRxiv · Nov 9, 2022 · PreprintImmunology

The PTEX pore component EXP2 is important for intrahepatic development during the Plasmodium liver stage

T. Hussain, J. Linera-Gonzalez, J. M. Beck, M. A. Fierro, G. R. Mair, R. C. Smith, J. R. Beck

This study uses a ribozyme-based approach to show EXP2 is essential for Plasmodium liver stage development, highlighting its role in the PTEX translocon at the hepatocyte-parasite interface.

bioRxiv · Oct 2, 2022Microbiology

Semi-field and surveillance data define the natural diapause timeline for Culex pipiens across the United States

E. N. Field, J. J. Shepard, M. E. Clifton, K. J. Price, B. J. Witmier, K. Johnson, B. Boze, C. Abadam, G. D. Ebel, P. M. Armstrong, C. M. Barker, R. C. Smith

The paper uses surveillance data to define the diapause timeline for Culex pipiens across the U.S., showing population declines during diapause receptivity and highlighting genetic factors affecting population trends.

bioRxiv · May 19, 2022Ecology

Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host

H. J. Loghry, H. Kwon, R. C. Smith, N. A. Sondjaja, S. Minkler, S. Young, N. J. Wheeler, M. Zamanian, L. Bartholomay, M. J. Kimber

This paper shows that extracellular vesicles from Brugia malayi microfilariae reduce melanization in Aedes aegypti mosquitoes by downregulating AAEL002590 and decreasing phenoloxidase activity.

bioRxiv · Apr 11, 2022 · PreprintImmunology

A tiger in the Upper Midwest: Surveillance and genetic data support the introduction and establishment of Aedes albopictus in Iowa, USA

D. R. Hall, R. E. Tokarz, E. N. Field, R. C. Smith

The paper documents the establishment of Aedes albopictus in Iowa, USA, through surveillance and genetic analysis, showing overwintering populations and urban-specific distribution.

bioRxiv · Oct 20, 2021 · PreprintEcology

Identification of a prostaglandin E2 receptor that regulates mosquito oenocytoid immune cell function in limiting bacteria and parasite infection

H. Kwon, D. R. Hall, R. C. Smith

This study identifies a prostaglandin E2 receptor in mosquitoes that modulates immune cell function to limit bacterial and Plasmodium infection.

bioRxiv · Aug 3, 2020 · PreprintImmunology

Single-cell analysis of mosquito hemocytes identifies signatures of immune cell sub-types and cell differentiation

H. Kwon, M. Mohammed, O. Franzen, J. Ankarklev, R. C. Smith

The paper uses scRNA-seq to identify immune cell subtypes and differentiation in mosquitoes, defining markers and showing the role of lozenge in oenocytoid fate.

bioRxiv · Jul 11, 2020Immunology

The 20-hydroxyecdysone agonist, halofenozide, promotes anti-Plasmodium immunity in Anopheles gambiae via the ecdysone receptor

R. A. Reynolds, H. Kwon, T. L. Alves e Silva, J. Olivas, J. Vega-Rodriguez, R. C. Smith

This study shows that halofenozide, a 20-hydroxyecdysone agonist, reduces Plasmodium infection in Anopheles gambiae by activating the ecdysone receptor via ultraspiracle, without affecting cellular immunity or AMP production.

bioRxiv · Jun 19, 2020Microbiology

20-hydroxyecdysone (20E) primes innate immune responses that limit bacteria and malaria parasite survival in Anopheles gambiae

R. A. Reynolds, H. Kwon, R. C. Smith

This study shows that 20-hydroxyecdysone primes immune responses in Anopheles gambiae, reducing bacteria and Plasmodium survival.

bioRxiv · Oct 28, 2019Immunology

Malaria parasite immune evasion and adaptation to its mosquito host is influenced by the acquisition of multiple blood meals

H. Kwon, R. A. Reynolds, M. L. Simoes, G. Dimopoulos, R. C. Smith

This study shows that additional blood meals affect Plasmodium parasite development differently in Anopheles mosquitoes, influencing oocyst numbers and immune evasion.

bioRxiv · Oct 15, 2019 · PreprintMicrobiology

Chemical depletion of phagocytic immune cells reveals dual roles of mosquito hemocytes in Anopheles gambiae anti-Plasmodium immunity

H. S. Kwon, R. C. Smith

This study uses chemical depletion to show mosquito hemocytes have dual roles in anti-Plasmodium immunity: recognizing ookinetes and producing prophenoloxidases to limit oocyst survival.

bioRxiv · Sep 27, 2018Immunology