Q. Dong

Cloud-Connected Patch-Worn Auscultation Device for Chest Sound Monitoring

The paper describes a wearable device for chest sound monitoring that transmits 10-second recordings via Bluetooth-Low-Energy and includes noise reduction features.

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair

The paper identifies the UNG-RPA interaction as determining whether uracil repair is high-fidelity or mutagenic in B cells.

Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy

This study identifies distinct growth and chaining properties in Clade 5 Clostridioides difficile strains using time-lapse microscopy, linked to the cmr switch sequence orientation.

Plasmonic Enhancement of Protein Function

This study demonstrates plasmonic enhancement of protein function in living cells by coupling designed nanoparticles to Archaerhodopsin proteins, increasing fluorescence and response speed.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence.

The paper identifies that longer inverted repeats in the flagellar switch region of C. difficile RT027 strains correlate with greater virulence and phenotypic heterogeneity in flagellar gene expression.

Uracil-DNA Glycosylase of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently of its Catalytic Residues

This paper identifies a non-enzymatic role for murine gammaherpesvirus 68 vUNG in forming a complex with viral DNA replication factors, independent of its catalytic activity.

Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

Early microbial intervention reduces diarrhea while improves later milk production in newborn calves

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo competition model

This study shows that B cell-intrinsic STAT3 supports gammaherpesvirus latency and suppresses interferon responses in mice, using a competitive infection model.

A bi-kinase module sensitizes and potentiates plant immune signaling

The paper identifies a Ca2+ sensing bi-kinase module that enhances NADPH oxidase activation through mutual trans-phosphorylation, enabling systemic immunity in plants.

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

Design and fabrication of a low-cost microfluidic cartridge with integrated pressure-driven check valve for molecular diagnostics platforms

The paper designs and tests a low-cost microfluidic cartridge with a pressure-driven check valve for molecular diagnostics, demonstrating fluid manipulation and integration with a benchtop LAMP system.

IKKalpha-Mediated Non-canonical NF-kappaB Signaling is Required to Support Murine Gammaherpesvirus 68 Latency In Vivo

This study shows that non-canonical NF-kappaB signaling via IKKalpha is essential for MHV68 latency in mice, but not for viral replication or reactivation in all cell types.

Microrisk Lab: an online freeware for predictive microbiology

Microrisk Lab is an online tool for microbial predictive modeling that performs parameter estimation and simulation, showing performance comparable to existing software.

Chroococcidiorella tianjinensis, gen. et sp. nov. (Trebouxiophyceae, Chlorophyta), a green alga arises from the cyanobacterium TDX16

The paper describes a new green alga, Chroococcidiorella tianjinensis, derived from a cyanobacterium through de novo organelle biogenesis and host DNA acquisition.