Author

J. Rylance

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:flow cytometry· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:metagenomics· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Mitsi· 5 shared H. Hill· 5 shared J. Reine· 5 shared S. Pojar· 5 shared C. Hales· 4 shared C. Solorzano· 4 shared D. M. Ferreira· 4 shared E. Nikolaou· 4 shared

Activity by Year

2018-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

E. Mitsi

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5 papers

Recent·Most cited

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

J. Reine, B. F. Carniel, C. Solorzano, E. Mitsi, S. Pojar, E. Nikolau, E. L. German, A. D. Hyder-Wright, H. Hill, C. Hales, L. Brown, V. Horsley, L. Hughes, S. Zaidi, V. Connor, , S. P. Jochems

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

bioRxiv · Mar 14, 2019 · PreprintImmunology

Defining mucosal immunity using mass cytometry following experimental human pneumococcal challenge

S. P. Jochems, K. de Ruiter, C. Solorzano, A. Voskamp, E. Mitsi, E. Nikolaou, B. F. Carniel, S. Pojar, E. German, J. Reine, A. Soares-Schanoski, H. Hill, R. Robinson, A. D. Hyder-Wright, C. Weight, , D. M. Ferreira

The paper uses mass cytometry to analyze nasal immune cells after pneumococcal challenge, identifying immune changes linked to colonization and host-pathogen interactions.

bioRxiv · Feb 11, 2019Immunology

Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization

E. Nikolaou, S. P. Jochems, E. Mitsi, S. Pojar, E. Negera, J. Reine, B. Carniel, A. Soares-Schanoski, V. Connor, H. Adler, S. R. Zaidi, C. Hales, H. Hill, A. Hyder-Wright, S. B. Gordon, , D. Ferreira

This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.

bioRxiv · Nov 5, 2018 · PreprintImmunology

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage

S. P. Jochems, F. Marcon, B. F. Carniel, M. Holloway, E. Mitsi, E. Smith, J. F. Gritzfeld, C. Solorzano, J. Reine, S. Pojar, E. Nikolaou, E. L. German, A. Hyder-Wright, H. Hill, C. Hales, , D. M. Ferreira

This study shows that influenza virus infection impairs innate immune responses to pneumococcal carriage in the nose, increasing bacterial density through cytokine-driven mechanisms.

bioRxiv · Jun 20, 2018Immunology

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

J. Rylance, W. A. de Steenhuijsen Piters, S. Pojar, E. Nikolaou, E. German, E. Mitsi, S. Jochems, B. Carniel, C. Solorzano, J. Reine, J. Gritzfeld, M. L. J. Chu, K. Arp, A. D. Hyder-Wright, H. Hill, , D. M. Ferreira

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.

bioRxiv · Jun 14, 2018Immunology