Author

V. Connor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:fluorescence / live-cell microscopy· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

C. M. Crump· 6 shared S. C. Graham· 5 shared C. Hales· 4 shared E. Mitsi· 4 shared H. Adler· 4 shared H. Hill· 4 shared J. Reine· 4 shared J. Rylance· 4 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersMicrobiology

C. M. Crump

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis

K. L. Nahas, V. Connor, K. J. Wijesinghe, H. G. Barrow, I. M. Dobbie, M. Harkiolaki, S. C. Graham, C. M. Crump

This study uses 3D correlative fluorescence and X-ray tomography to analyze HSV-1 mutants, revealing roles of viral proteins in morphogenesis and showing envelopment occurs via budding.

bioRxiv · Mar 13, 2024Microbiology

Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

T. H. Benedyk, V. Connor, E. R. Caroe, M. Shamin, D. I. Svergun, J. E. Deane, C. M. Jeffries, C. M. Crump, S. C. Graham

This paper shows HSV-1 protein pUL21 activates CERT to increase ceramide to sphingomyelin conversion, but does not affect virus replication or spread.

bioRxiv · Jun 1, 2022Microbiology

Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection

K. L. Nahas, V. Connor, K. M. Scherer, C. F. Kaminski, M. Harkiolaki, C. M. Crump, S. C. Graham

This study uses cryo-soft-X-ray tomography to image HSV-1 infected cells in near-native state, revealing morphological changes in organelles like mitochondria and cytoplasmic vesicles.

bioRxiv · Oct 11, 2021Microbiology

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

T. H. Benedyk, J. Muenzner, V. Connor, Y. Han, K. Brown, K. J. Wijesinghe, Y. Zhuang, S. Colaco, G. A. Stoll, O. S. Tutt, S. Svobodova, D. I. Svergun, N. A. Bryant, J. E. Deane, A. E. Firth, , S. C. Graham

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

bioRxiv · Apr 13, 2021Microbiology

Spatiotemporal analysis of host cell modification during herpes simplex virus 1 replication

K. M. Scherer, J. D. Manton, T. K. Soh, L. Mascheroni, V. Connor, C. M. Crump, C. F. Kaminski

This study uses a recombinant reporter virus to analyze the spatiotemporal dynamics of host cell modifications during herpes simplex virus 1 replication.

bioRxiv · Dec 22, 2019 · PreprintMicrobiology

Herpes simplex virus-1 pUL56 degrades GOPC to alter the plasma membrane proteome

T. K. Soh, C. T. R. Davies, J. Muenzner, V. Connor, C. R. Bouton, H. G. Barrow, C. Smith, E. Emmott, R. Antrobus, S. C. Graham, M. P. Weekes, C. M. Crump

This study identifies HSV-1 pUL56 as a protein that degrades GOPC, altering the plasma membrane proteome by affecting signaling receptors.

bioRxiv · Aug 8, 2019Microbiology

Pneumococcal Colonisation is an Asymptomatic Event in Healthy Adults using an Experimental Human Colonisation Model.

A. Trimble, V. Connor, R. Robinson, C. Hancock, D. Wang, S. Gordon, D. Ferreira, A. Wright, A. Collins

This study investigates whether pneumococcal colonisation in healthy adults is symptomatic using an experimental challenge model, finding it asymptomatic regardless of bacterial density or viral co-colonisation.

bioRxiv · Jun 3, 2019Microbiology

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

J. Reine, B. F. Carniel, C. Solorzano, E. Mitsi, S. Pojar, E. Nikolau, E. L. German, A. D. Hyder-Wright, H. Hill, C. Hales, L. Brown, V. Horsley, L. Hughes, S. Zaidi, V. Connor, , S. P. Jochems

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

bioRxiv · Mar 14, 2019 · PreprintImmunology

Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization

E. Nikolaou, S. P. Jochems, E. Mitsi, S. Pojar, E. Negera, J. Reine, B. Carniel, A. Soares-Schanoski, V. Connor, H. Adler, S. R. Zaidi, C. Hales, H. Hill, A. Hyder-Wright, S. B. Gordon, , D. Ferreira

This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.

bioRxiv · Nov 5, 2018 · PreprintImmunology

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage

S. P. Jochems, F. Marcon, B. F. Carniel, M. Holloway, E. Mitsi, E. Smith, J. F. Gritzfeld, C. Solorzano, J. Reine, S. Pojar, E. Nikolaou, E. L. German, A. Hyder-Wright, H. Hill, C. Hales, , D. M. Ferreira

This study shows that influenza virus infection impairs innate immune responses to pneumococcal carriage in the nose, increasing bacterial density through cytokine-driven mechanisms.

bioRxiv · Jun 20, 2018Immunology

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

J. Rylance, W. A. de Steenhuijsen Piters, S. Pojar, E. Nikolaou, E. German, E. Mitsi, S. Jochems, B. Carniel, C. Solorzano, J. Reine, J. Gritzfeld, M. L. J. Chu, K. Arp, A. D. Hyder-Wright, H. Hill, , D. M. Ferreira

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.

bioRxiv · Jun 14, 2018Immunology