BiochemistrybioRxiv
Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells
A. B. Grenell, C. Singh, M. Raju…·B. Anand-Apte
This study shows that TIMP3 mutations in RPE cells increase glycolytic activity and disrupt glutamine metabolism, linking these changes to Sorsbys Fundus Dystrophy.