M. Ogawa

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

The paper identifies a conserved mechanism, RePrESS, by which autoreactive innate-like T cells maintain tolerance through rewiring of the TCR signalosome.

Testing immediate dosage compensation by irradiation of heavy-ion beams to Drosophila miranda

This study tests if immediate dosage compensation occurs in Drosophila miranda by inducing neo-Y deletions and analyzing gene expression in F1 males.

Comprehensive O-GlcNAc glycoproteomics on NOTCH1 EGF repeats implicated unique Lewis X epitopes in mammals

The paper identifies unique Lewis X epitopes on NOTCH1 EGF repeats through O-GlcNAc glycoproteomics, revealing structural diversity and fucosylation patterns in mammals.

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

This study identifies conserved transcription factors and genes involved in gliotoxin protection in Aspergillus species through RNA-sequencing and deletion screening.

Generation of functional ciliates cholangiocytes from human pluripotent stem cells

This study generates functional cholangiocytes from human pluripotent stem cells that exhibit mature characteristics and can be used for drug testing and disease modeling.

Lysosomal microautophagic pathway links proteostasis to protein aggregation disease

This study identifies SIDT2 as a mediator of microautophagy that delivers cytosolic proteins into lysosomes, linking proteostasis to protein aggregation disease.

DNA methylation site loss for plasticity-led novel trait genetic fixation

The paper investigates how epigenetic regulation loss leads to genetic fixation of novel traits in medaka fish through methylation profiling and CRISPR/Cas9 deletion.

RT-qPCR analyses on the osteogenic differentiation from human iPS cells: An investigation of reference genes

The paper evaluates reference genes for RT-qPCR in osteogenic differentiation of human iPS cells, finding TBP as the most stable and GAPDH/ACTB as unsuitable.