Cancer BiologybioRxiv
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
S. Wang, K. Lee, S. Gray…·R. Chahwan
This study compares Exo1DA/DA mice with nuclease-dead EXO1 to Exo1-/- and Exo1+/+ mice to show EXO1 has both enzymatic and scaffolding roles in DNA repair, immune response, and tumor suppression.
DOI 10.1093/nar/gkac616