Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
S. Wang, K. Lee, S. Gray, Y. Zhang, C. Tangcatherin, R. Morrish, E. Tosti, J. van Oers, P. Cohen, T. MacCarthy, S. Roa, M. D. Scharff, W. Edelmann, R. Chahwan
This study compares Exo1DA/DA mice with nuclease-dead EXO1 to Exo1-/- and Exo1+/+ mice to show EXO1 has both enzymatic and scaffolding roles in DNA repair, immune response, and tumor suppression.
bioRxiv · Oct 5, 2021Cancer Biology