Cancer BiologybioRxiv
TIRAP drives myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the marrow microenvironment
R. Ibrahim, A. Gopal, M. Fuller…·A. Karsan
This paper identifies TIRAP as a driver of myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the bone marrow microenvironment, independent of T cell function or pyroptosis.
DOI 10.1084/jem.20200731