J. Lam

Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity

The paper screens 133 chemicals for reproductive toxicity using C. elegans assays and compares results with ToxCast data, identifying 13 toxicants including QACs.

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

Paridiprubart inhibits TLR4-dependant NF-κB activation by multiple pathogens

This study shows that paridiprubart, a TLR4 inhibitor, suppresses NF-κB activation by multiple pathogens including SARS-CoV-2 and bacterial agents.

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue

This study uses 3D electron microscopy to analyze mitochondrial cristae morphology in mouse brown adipose tissue across aging, finding significant structural changes in aged tissue.

Antibody avidity and multi-specificity combined to confer protection against SARS-CoV-2 and resilience against viral escape

This study develops a multimeric antibody platform (Multabody) that enhances neutralization potency and breadth against SARS-CoV-2 and its variants through avidity and multi-specificity.

Dually targeted proteins regulate proximity between peroxisomes and partner organelles

The paper investigates dually targeted proteins in yeast and shows they act as dynamic tethers between peroxisomes and partner organelles, contributing to their proximity and communication.

Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

Practices for Measuring 3D Organelle Morphology and Generating Surfaces with Amira

The paper introduces a standardized protocol using Amira software to quantify 3D organelle morphology from SBF-SEM data, demonstrating its application to mitochondria and ER structures.

A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ

This paper introduces a standardized method using ImageJ to quantify subcellular organelle morphology in TEM images, focusing on mitochondria, ER, lysosomes, and autophagosomes.

TIRAP drives myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the marrow microenvironment

This paper identifies TIRAP as a driver of myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the bone marrow microenvironment, independent of T cell function or pyroptosis.

Genome-wide transposon screen of a Pseudomonas syringae mexB mutant reveals the substrates of efflux transporters

The paper identifies efflux transporter substrates in Pseudomonas syringae by screening a transposon mutant library in a mexB mutant background, revealing redundant transporters with overlapping substrate specificities.

The mutational decay of male and hermaphrodite competitive fitness in the androdioecious nematode C. elegans, in which males are naturally rare

The paper estimates mutational effects on male and hermaphrodite competitive fitness in C. elegans, finding males decay faster due to higher mutation rates and mating variability.