Author

J. Yap

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Hu· 2 shared J. Yuan· 2 shared M. Wang· 2 shared W. H. Ng· 2 shared A. K. Tchoupa· 1 shared A. S. G. Lee· 1 shared A. W. Bradshaw· 1 shared B. Chia· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

J. Hu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The staphylococcal type VII secretion system effector EsxC impacts daptomycin sensitivity through controlling bacterial cell envelope integrity

V. Smith, G. Chandrasekharan, K. Watkins, R. G. Maset, J. Yap, S. Perrier, A. K. Tchoupa, M. Unnikrishnan

This study shows that the T7SS effector EsxC in S. aureus affects daptomycin sensitivity by modulating cell membrane integrity.

bioRxiv · Nov 20, 2023 · PreprintMicrobiology

In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury.

S. Giannakopoulos, D. P. Strange, B. Jiyarom, O. Abdelaal, A. W. Bradshaw, V. R. Nerurkar, M. A. Ward, J. Bakse, J. Yap, S. Vanapruks, W. Boisvert, M. Tallquist, C. Shikuma, H. Sadri-Ardekani, P. Clapp, , S. Verma

This study shows SARS-CoV-2 does not directly infect human testicular cells but causes injury through bystander effects from systemic inflammation or viral antigens.

bioRxiv · Sep 21, 2022 · PreprintMicrobiology

Development and evaluation of a rapid on-site water pathogen detection system for water quality monitoring

J. Y. Chia, Y. P. Tay, D. Poh, B. H. Tay, E. Koh, J. Teo, J. Yap, M. Lim, L. T. Soh, Y. K. Lee, C.-L. K. Lee

This paper develops a rapid on-site DNA-based detection system for Pseudomonas aeruginosa with high sensitivity and specificity, reducing detection time to 45 minutes.

bioRxiv · Aug 10, 2019 · PreprintMicrobiology

The Dimer-dependent Catalytic Activity of RAF Family Kinases Is Revealed Through Characterizing Their Oncogenic Mutants

J. Yuan, W. H. Ng, P. Y. P. Lam, Y. Wang, H. Xia, J. Yap, S. P. Guan, A. S. G. Lee, M. Wang, M. Baccarini, J. Hu

This study identifies dimer-dependent catalytic activity in RAF family kinases through analysis of oncogenic mutants, revealing differential inhibitor resistance and MEK phosphorylation mechanisms.

bioRxiv · Jun 4, 2018Cancer Biology

AMPKi overcomes the paradoxical activation of CRAF driven by RAF inhibitors through blocking the 14-3-3 binding to its carboxyl-terminus

J. Yuan, W. H. Ng, J. Yap, B. Chia, X. Huang, M. Wang, J. Hu

This study identifies AMPKi as a compound that blocks 14-3-3 binding to CRAF, overcoming RAF inhibitor resistance by preventing paradoxical CRAF activation in cancer cells.

bioRxiv · Jan 30, 2018Cancer Biology