J.-i. Kishikawa

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

Mechanism of ATP hydrolysis dependent rotation of ATP synthases

The paper uses cryo-EM to capture catalytic intermediates of ATP synthase F1 domain, revealing how ATP hydrolysis couples to mechanical rotation in 120-degree steps.

Structural transition of the ground-state structure to steady-state structures by sequential binding of ATP to V/A-ATPase

The paper identifies intermediate structures of V/A-ATPase during ATP activation using cryo-EM, showing how the ground-state structure transitions to steady-state through sequential ATP binding.

Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae

This study presents cryo-EM structures of Na+-NQR from Vibrio cholerae with and without inhibitors, revealing cofactor arrangements and inhibitor binding sites.

Structural snapshots of V/A-ATPase reveal a new paradigm for rotary catalysis

The paper determines atomic models of V/A-ATPase catalytic intermediates, revealing a ratchet-like mechanism for unidirectional rotation instead of a power stroke model.

The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines

The paper shows the Delta variant can escape NTD antibodies and gain infectivity when specific RBD mutations are present, suggesting the need for updated vaccines.

The mechanical inhibition of the isolated Vo from V-ATPase for proton conductance

The paper determines the cryo-EM structures of holo V/A-ATPase and isolated Vo to elucidate the auto-inhibited form of Vo and its regulation of proton conductance.