M. Kimura

Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State

The paper shows that inter-species mRNA transfer from mouse embryonic stem cells to human pluripotent stem cells reprograms them to a naive-like state through specific transcription factors.

Inhibitors of cannabinoid receptor 1 suppress the cellular entry of Lujo virus

This study identifies CB1 receptor antagonists as inhibitors of Lujo virus entry by suppressing viral membrane fusion and reducing infectivity in vitro.

A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis

This paper introduces a microarray 3D bioprinting platform with pillar and perfusion plates for high-throughput human organoid culture and analysis.

Physicochemical properties of the vacuolar membrane and cellular factors determine formation of vacuolar invaginations

The paper shows that vacuolar invaginations in yeast result from changes in membrane physicochemical properties and cellular factors like Hfl1 and the ESCRT machinery.

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort

The paper analyzes the gut virome in a large cohort, identifying factors influencing virome diversity and its relationship with host and environmental variables.

Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25 by silkworm, Bombyx mori, and its biochemical analysis.

This study expresses and purifies recombinant Pvs25 from silkworms, demonstrating its potential as a malaria transmission-blocking vaccine candidate with high immunogenicity.

Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells

This study develops yolk sac-like organoids from hiPSCs to generate multipotent hematopoietic progenitor cells in a scalable and xeno-free system.

Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection

This study shows that a common genetic variant in the FURIN gene affects SARS-CoV-2 infection in vitro, suggesting genetic factors contribute to clinical variability in COVID-19.

Development of a reverse transcription polymerase chain reaction for the detection of severe fever with thrombocytopenia syndrome virus from suspected infected animals

This paper develops an RT-PCR assay to detect SFTSV in suspected animals, identifying 5 positive cases among 56 samples and demonstrating its sensitivity and specificity.

Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein

This study evaluates SARS-CoV-2 neutralizing antibodies using a pseudotyped virus assay and compares results with immunofluorescence assay findings.

Efficient callus induction and completion of regeneration in kenaf Hibiscus cannabinus

This study completes the regeneration process in kenaf by inducing callus and shoots from cotyledon explants, enabling genetic modification for improved material properties.