J.-T. A. Chi

This study shows that O-GlcNAcylation regulates NF-L assembly and function, and CMT mutations disrupt this process, linking glycosylation defects to neurodegeneration.

This paper analyzes serum metabolomics from a low-carbohydrate diet trial in prostate cancer patients to identify metabolic changes associated with slower tumor growth.

This study shows that STK3, typically a tumor suppressor, promotes prostate cancer growth and identifies STK3 inhibitors with therapeutic potential.

This study investigates how low-carbohydrate diets affect metabolic changes in prostate cancer patients undergoing androgen deprivation therapy, finding that the diet reverses some adverse metabolic effects while slightly lowering androgen levels.

This study quantifies the heterogeneous timing of asexual cycles in Plasmodium falciparum using time-lapse microscopy and finds that unsynchronized cultures have a bimodal burst time distribution and that artificial synchronization does not fundamentally alter cycle dynamics.

This study shows that G9a promotes breast cancer recurrence by repressing pro-inflammatory genes, leading to necroptosis when inhibited.

This study shows that inhibiting xCT/SLC7A11 induces ferroptosis in myofibroblastic hepatic stellate cells, reducing liver fibrosis without worsening liver injury.

This study identifies MESH1 as a cytosolic NADPH phosphatase that promotes cell survival under ferroptosis by maintaining NADPH levels and induces transcriptional changes resembling bacterial stringent response.