BiophysicsbioRxiv
Novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
K. Amporndanai, X. Meng, H. Yang…·W. Shang
This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.
DOI 10.1038/s41467-021-23313-7