H. Ling

HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

This study shows that inhibiting HDAC10 increases SPARC expression, which suppresses melanoma growth and restores sensitivity to BRAF inhibitors.

Absolute Quantification of Microbiota in Shotgun Sequencing Using Host Cells or Spike-Ins

This paper introduces methods to calculate absolute microbial abundances in shotgun sequencing using spike-ins or host cells, showing consistent results with qPCR and manufacturer values.

Effect of tuft-IL-25-ILC2 pathway on mouse small intestine stimulated by Trichinella spiralis ES antigen

This study investigates how Trichinella spiralis ES antigen affects the Tuft-IL-25-ILC2 pathway in mouse small intestine, showing increased goblet cells and Tuft cells with antigen stimulation and reduced levels when IL-25 is blocked.

A membrane-associated condensate drives paternal epigenetic inheritance in C. elegans

This study identifies a phase separation mechanism involving PEI-1 that enables paternal epigenetic inheritance in C. elegans by securing WAGO-3 in sperm.

Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides

This study replaces the amide group in pantothenamides with heteroaromatic rings to improve antiplasmodial activity against Plasmodium species.

Comparative Population Genomics of Bread Wheat (Triticum aestivum) Reveals Its Cultivation and Breeding History in China

This study uses genome-wide resequencing of wheat landraces and cultivars to trace the genetic diversity and breeding history of bread wheat in China.