P. Yang

Cellular stemness identifies high-risk ductal carcinoma in situ and offers a therapeutic interception opportunity

This study identifies stemness features in luminal hormone-responsive cells within DCIS that correlate with invasive progression and shows that targeting FOXA1 reduces tumor growth.

A high-resolution model of gene expression during Gossypium hirsutum (cotton) fiber development

This study presents a high-resolution transcriptomic analysis of cotton fiber development, identifying key gene expression shifts and regulatory networks during secondary wall synthesis.

Structural and functional analysis of the Nipah virus polymerase complex

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Colorectal ALOX15 as a host factor determinant of EPA and DHA effects on colorectal carcinogenesis

This study shows that ALOX15 expression modulates EPA and DHA effects on colorectal carcinogenesis by promoting resolvin generation, which suppresses pro-tumorigenic inflammation.

Daily glycome and transcriptome profiling reveals polysaccharide structures and glycosyltransferases critical for cotton fiber growth

This study profiles the glycome and transcriptome of cotton fibers daily to identify polysaccharide structures and glycosyltransferases critical for fiber growth and quality.

Discovery of the First-in-class G9a/GLP PROTAC Degrader

This paper discovers a first-in-class PROTAC degrader for G9a/GLP, showing effective degradation and superior anticancer activity compared to existing inhibitors.

Structural basis for VLDLR recognition by eastern equine encephalitis virus

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A

The paper identifies microtubule-targeting agents that induce CENP-A accumulation by destabilizing Cdh1, linking microtubule dynamics to CENP-A proteolysis.

Avirulent ME49Δgra5 Protecting Hosts Against Toxoplasma gondii Infection and Breast Tumors

This paper shows that the gra5 knockout T. gondii strain ME49Δgra5 is avirulent, prevents cyst formation, and protects against T. gondii infection and breast tumor growth in mice.

FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype

This study uses deep learning on plasma extracellular vesicle RNA to predict cancer subtypes, monitor treatment effects, and identify gene fusions and neoepitopes without tissue sampling.

Vimentin enables directional cell migration by coordinating focal adhesion organization and dynamics

This study shows vimentin stabilizes focal adhesion alignment during directed fibroblast migration, enabling persistent directional movement.

Rab7/Retromer-based endolysosomal trafficking facilitates effector secretion and host invasion in rice blast

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

Myeloid cell evolution uncovered by shrimp immune cell analysis at single-cell resolution

This study uses single-cell RNA sequencing to analyze shrimp hemocytes, revealing evolutionary parallels between invertebrate and vertebrate myeloid cells.

Mammalian D-Cysteine controls insulin secretion in the pancreas

This paper identifies D-cysteine as a regulator of insulin secretion in the pancreas, showing its role in modulating cAMP, CREB, and DNA methylation in islets.

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

Single-cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction

This study uses single-cell RNA sequencing to analyze cardiac immune cell dynamics after myocardial infarction in mice, identifying key immune subsets and their roles in disease progression.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

Reciprocity between retrograde signal and putative metalloprotease reconfigures plastidial metabolism and structure

The paper shows that the retrograde signal MEcPP increases VIR3 abundance, reducing target enzymes and altering plastid metabolism and structure under stress.

Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for IFT of radial spokes

The paper identifies ARMC2/PF27 as a specific cargo adapter required for IFT of radial spokes in Chlamydomonas, ensuring their assembly along flagella.

On the use of facial and neck cooling to improve indoor occupant thermal comfort in warm conditions

This study evaluates two wearable face and neck cooling fans to improve indoor thermal comfort and reduce HVAC energy use in warm conditions.

Identification and expression analysis of Shaker K+ channel genes in millet (Setaria italica) under abiotic stresses

This study identifies ten Shaker K+ channel genes in foxtail millet and analyzes their expression under abiotic stresses and ABA treatment, revealing distinct regulation patterns.

A deep learning-based iterative digital pathology annotation tool

This paper introduces a deep learning-based tool for digital pathology annotation that reduces annotation time while maintaining accuracy, validated on CAMELYON16 and TCGA datasets.

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

Characterization of a glycolipid glycosyltransferase with broad substrate specificity from the marine bacterium Candidatus Pelagibacter sp. HTCC7211

This paper characterizes a glycolipid glycosyltransferase (GTcp) from Candidatus Pelagibacter sp. HTCC7211, showing its broad substrate specificity and role in glycoglycerolipid synthesis under phosphorus stress.