Author

K. Barbosa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Deshpande· 2 shared A. J. Deshpande· 2 shared Y. Sun· 2 shared A. Brown· 1 shared A. Ghosh· 1 shared A. Minkina· 1 shared B. Barbeau· 1 shared B.-R. Chen· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. Deshpande

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Author profile →

3 papers

Recent·Most cited

High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of HOX/MEIS Activation in Acute Myeloid Leukemia

K. Barbosa, A. Deshpande, M. E. Perales, P. Xiang, R. Murad, A. Minkina, N. A. Robertson, F. Schischlik, X. Lei, Y. Sun, A. Brown, D. Amend, I. Jeremias, J. G. Doench, K. Humphries, , A. J. Deshpande

The paper identifies SGF29 as a novel chromatin regulator of MEIS1 and AML oncogenes, showing its role in leukemogenesis and potential as a drug target.

bioRxiv · Dec 12, 2022 · PreprintCancer Biology

Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1

K. Barbosa, A. Ghosh, A. Deshpande, B.-R. Chen, Y. Sun, M. Weetall, S. A. Armstrong, S. K. Bohlander, A. J. Deshpande

This study shows that BMI1 is overexpressed in CALM-AF10-positive leukemias and that inhibiting BMI1 with PTC209 or PTC596 reduces leukemia growth and prolongs survival.

bioRxiv · Jan 18, 2019Cancer Biology

HIV-1 antisense protein of different clades induces autophagy and associates to the autophagy factor p62

Z. Liu, C. Torresilla, Y. Xiao, C. Cate, K. Barbosa, E. Rassart, S. Cen, B. Barbeau

This study shows that HIV-1 antisense protein (ASP) from different clades induces autophagy through interaction with p62 and is regulated by autophagy and ubiquitin/proteasome systems.

bioRxiv · May 11, 2018Microbiology