Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis
C. Shu, R. Jin, Q. Niu, D. Cicka, S. Doyle, A. Wahafu, D. Fan, X. Zheng, Y. Du, A. Ivanov, D. Doxie, K. Dhodapkar, J. Carlisle, T. Owonikoko, S. Ramalingam, , H. Fu
The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.
bioRxiv · Sep 17, 2021 · PreprintCancer Biology