D. Fan

Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

This study identifies a zebrafish model of IBD by knocking out Ctla-4, showing similar intestinal inflammation and immune dysregulation to mammalian IBD.

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

Photobody formation spatially segregates two opposing phytochrome B signaling actions to titrate plant environmental responses

The paper shows that phytochrome B forms photobodies to spatially separate and balance opposing effects on PIF5, enabling environmentally sensitive regulation of plant responses.

The mitochondrial deoxyguanosine kinase is required for female fertility in mice

This study shows that Dguok knockout causes female infertility in mice by impairing ovarian development, oocyte maturation, and mitochondrial function.

Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

This study uses single-cell RNA sequencing to show zebrafish kidney cells can generate both blood cells and adaptive antiviral immunity, acting as a dual-functional organ.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Biosynthetic Enzyme-guided Disease Correlation Connects Gut Microbial Metabolites Sulfonolipids to Inflammatory Bowel Disease Involving TLR4 Signaling

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10

This paper determines the crystal structure of DOCK10DHR2, revealing its dual specificity for CDC42 and RAC, and a unique 2:1 stoichiometry in complex with RAC.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

The paper identifies mutation-directed neo-protein-protein interactions in cancer using a high-throughput screening platform, revealing therapeutic opportunities through neo-interaction rewiring.

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

Effects of Emodin, a Plant-Derived Anthraquinone, on TGFβ1-Induced Cardiac Fibroblast Activation and Function

This study shows emodin reduces TGFβ1-induced cardiac fibroblast activation and collagen accumulation by modulating key signaling pathways.

Spike Protein of SARS-CoV-2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

Emergent collective organization of bone cells in complex curvature fields

This study shows micro-engineered substrates with curvature variations induce collective spatiotemporal organization of preosteoblasts, revealing curvature-guided cell behavior and mechanical regulation.

Co-expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 Infection

The paper identifies a corneal mitochondrial susceptibility module linked to SARS-CoV-2 infection by analyzing co-expression and interaction networks of ACE2 and related genes.

Cross-Protection Against Zika Virus Infection Conferred by a Live Attenuated Japanese Encephalitis SA14-14-2 Vaccine

This study shows that the JE vaccine SA14-14-2 protects mice against ZIKV through cross-reactive T cell immunity rather than antibodies.

The microRNA476a/RFL module regulates adventitious root formation through a mitochondria-dependent pathway in Populus

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

Inhibition of Osteoblast Proliferation and Migration by Exogenous and Endogenous Formaldehyde

This study shows that formaldehyde inhibits osteoblast proliferation and migration via the FoxO1 signaling pathway in mouse cells.

Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis

This study shows that PLEKHO1 in osteoblasts worsens joint inflammation in RA and promotes bone formation, suggesting it as a therapeutic target.