K. E. Kadler

The paper models collagen fibril self-assembly in embryonic mouse tendon, showing that fibrils form extracellularly through a phase-transition mechanism, supported by experimental data.

This study shows that BMAL1, a circadian clock factor, regulates ECM homeostasis and cell fate in the intervertebral disc, with its loss causing ECM dysregulation and osteogenic differentiation.

This study shows that Mmp14 regulates circadian rhythms and matrisome homeostasis in tendon fibroblasts by controlling collagen fibril synthesis and crosslinking.

This study shows that circadian-regulated endocytic recycling is essential for collagen fibril assembly and is disrupted in fibrosis.

This study identifies 35 FDA-approved drugs that reduce SARS-CoV-2 replication in human cells, including amodiaquine and vitamin D3.

This study uses circadian time-series proteomics to identify daily protein abundance changes in mouse articular cartilage, revealing rhythmic proteins and their dysregulation in osteoarthritis and aging.

The paper identifies a circadian mechanism regulating collagen synthesis, assembly, and degradation to maintain tissue homeostasis in mice.

The paper shows that BiP and chemical chaperones strengthen circadian rhythms in fibroblasts under ER stress and prevent ER stress in tendon by regulating collagen synthesis.