Author

K. Ikuta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

A. Burchert· 1 shared A. Du· 1 shared A. M. Hartmann· 1 shared A. Neubauer· 1 shared A. Nist· 1 shared A. Pagenstecher· 1 shared A. Shibuya· 1 shared A. Shimba· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Burchert

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Generation and therapeutic efficacy of the novel Fc-modified cross-neutralizing human monoclonal antibodies against dengue virus

S. Injampa, S. Benjathummarak, S. Keadsanti, W. Puangmanee, A. Yamanaka, T. Sasaki, K. Ikuta, P. Ramasoota, P. Pitaksajjakul

This paper develops two Fc-modified human monoclonal antibodies that neutralize all dengue virus serotypes without causing antibody-dependent enhancement or complement activation.

bioRxiv · May 25, 2023 · PreprintImmunology

Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

T. Asahi, S. Abe, G. Cui, A. Shimba, T. Nabekura, H. Miyachi, S. Kitano, K. Ohira, J. M. Dijkstra, M. Miyazaki, A. Shibuya, H. Ohno, K. Ikuta

The paper identifies a novel liver-specific ILC1 subset lacking IL-7 receptor that develops from fetal liver progenitors and exhibits constitutive cytotoxic activity.

bioRxiv · Nov 3, 2022Immunology

IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

D. Das Gupta, C. Paul, N. Samel, M. Bieringer, D. Staudenraus, F. Marini, H. Raifer, L. Menke, L. Hansal, B. Camara, E. Roth, P. Daum, M. Wanzel, M. Mernberger, A. Nist, , M. Lohoff

This study shows IRF4 deficiency leads to B cell leukemia via Jak3 mutations that increase IL-7 sensitivity, and JAK inhibition improves survival in a mouse model.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B

T. Matsumura, S. Amatsu, R. Misaki, M. Yutani, A. Du, T. Kohda, K. Fujiyama, K. Ikuta, Y. Fujinaga

This study develops fully human monoclonal antibodies against BoNT/B that show potent neutralization activity and broad subtype coverage, with therapeutic and prophylactic effects in mice.

bioRxiv · Dec 18, 2019Microbiology