A. Du

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

A robotic system for automated genetic manipulation and analysis of Caenorhabditis elegans

This paper introduces a robotic system for automated genetic manipulation of C. elegans, demonstrating reliability and throughput comparable to manual methods.

Recombinant HcGAPDH Protein Expressed on Probiotic Bacillus subtilis Spores Protects Sheep from Haemonchus contortus Infection by Inducing both Humoral and Cell-mediated Responses

This paper shows that recombinant Bacillus subtilis spores expressing H. contortus GAPDH protect sheep from infection by boosting immune responses and reducing parasite burden.

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B

This study develops fully human monoclonal antibodies against BoNT/B that show potent neutralization activity and broad subtype coverage, with therapeutic and prophylactic effects in mice.