This paper provides a guide to calibrating FCS and PIE-FRET measurements using biological samples to determine diffusion coefficients and FRET efficiency.

bioRxiv · Jan 25, 2024 · PreprintBiophysics

Complex multiple introductions drive fall armyworm invasions into Asia and Australia

R. Rane, T. Walsh, P. Lenancker, A. Gock, D. T. Hang, N. V. Liem, T. N. Khin, D. Amalin, K. Chittarath, M. Faheem, A. Sivapragasam, S. S. Thanarajoo, Y. A. Trisyono, S. Khay, J. Kim, , W. T. Tay

The paper uses population genomic analysis to trace multiple introductions of fall armyworm into Asia and Australia, showing human-assisted spread via trade and identifying genetic melting pot dynamics.

bioRxiv · Jun 11, 2022 · PreprintEvolutionary Biology

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Z. Wang, F. Schmidt, Y. Weisblum, F. Muecksch, C. O. Barnes, S. Finkin, D. Schaefer-Babajew, M. Cipolla, C. Gaebler, J. A. Lieberman, T. Y. Oliveira, Z. Yang, M. E. Abernathy, K. E. Huey-Tubman, A. Hurley, , M. C. Nussenzweig

This study examines antibody and memory B cell responses to mRNA vaccines against SARS-CoV-2 and assesses their effectiveness against emerging variants.

Nature · Feb 10, 2021Peer-reviewedImmunology

Evolution of Antibody Immunity to SARS-CoV-2

C. Gaebler, Z. Wang, J. C. C. Lorenzi, F. Muecksch, S. Finkin, M. Tokuyama, A. Cho, M. Jankovic, D. Schaefer-Babajew, T. Y. Oliveira, M. Cipolla, C. Viant, C. O. Barnes, A. Hurley, M. Turroja, , R. Patel

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

bioRxiv · Nov 3, 2020Immunology

Genomic balancing selection is key to the invasive success of the fall armyworm

S. Yainna, W. T. Tay, E. Fiteni, F. Legeai, A.-L. Clamens, S. Gimenez, M. Frayssinet, R. Asokan, C. Kalleshwaraswamy, S. Deshmukh, R. L. Meagher, C. A. Blanco, P. Silvie, T. Brevault, A. Dassou, , K. Nam

This study shows genomic balancing selection restored heterozygosity in the Fall armyworm, enabling its global invasion success despite population bottlenecks.

bioRxiv · Jun 17, 2020 · PreprintEvolutionary Biology

Analysis of High Molecular Weight RNA-induced silencing complex (HMW-RISC) in CD8+ T cells identifies miR-7 as a modulator of T cell activation

M. Toivakka, K. Gordon, S. Kumar, R. Zamoyska, A. Buck

The paper identifies miR-7 as a modulator of T cell activation by showing its enrichment in HMW-RISC and its role in suppressing IL-2 signaling and metabolic processes.

bioRxiv · May 17, 2020 · PreprintImmunology

Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals

D. F. Robbiani, C. Gaebler, F. Muecksch, J. Cetrulo Lorenzi, Z. Wang, A. Cho, M. Agudelo, C. Barnes, S. Finkin, T. Hagglof, T. Oliveira, C. Viant, A. Hurley, K. Millard, R. Kost, , Nuss

The paper analyzes antibody responses in convalescent individuals, finding low neutralizing titers but rare potent RBD-specific antibodies with broad antiviral potential.

bioRxiv · May 13, 2020Immunology

Multiple incursion pathways for Helicoverpa armigera in Brazil show its genetic diversity spreading in a connected world

J. A. Arnemann, S. H. Roxburgh, T. Walsh, J. V. Guedes, K. Gordon, G. Smagghe, W. T. Tay

The paper analyzes mtDNA haplotypes of Helicoverpa armigera in South America to show multiple incursion pathways, indicating independent introductions rather than a single origin.

bioRxiv · Sep 9, 2019Evolutionary Biology

Take out the rubbish - Removing NUMTs and pseudogenes from the Bemisia tabaci cryptic species mtCOI database

D. Kunz, W. T. Tay, S. Elfekih, K. Gordon, P. J. De Barro

The paper identifies and removes NUMTs, pseudogenes, and low-quality sequences from mtCOI datasets to improve species identification in Bemisia tabaci cryptic species.

bioRxiv · Aug 5, 2019 · PreprintEvolutionary Biology