M. Tokuyama

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

This study investigates whether COVID-19 mRNA vaccination affects pregnancy outcomes or induces anti-syncytin-1 antibodies, finding no evidence of fetal defects or increased antibody levels.

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

This paper develops a multiplex RT-qPCR assay for SARS-CoV-2 detection that uses existing primer/probe sets and reduces reagents, costs, time, and labor compared to singleplex assays.

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

The paper identifies an endogenous retrovirus envelope protein, ERV-K102, elevated in SLE patients, which is activated by SLE IgG to promote neutrophil activation and NET formation.

This study identifies SNERV, a suppressor of endogenous retrovirus expression, as a lupus susceptibility gene, showing its role in preventing ERV overexpression and associated nephritis.

This study shows that human APOBEC3G prevents the emergence of infectious endogenous retroviruses in mice, demonstrating its in vivo antiviral activity against ERVs.

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.