H. Ohno

Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy

This study introduces ExAPC microscopy for label-free visualization of intracellular structures, showing its ability to resolve biomolecular condensates, lipid droplets, and mitochondria with high spatiotemporal resolution.

Gut microbiome-based prediction of autoimmune neuroinflammation

The paper identifies a microbial risk factor for autoimmune neuroinflammation by analyzing microbiota compositions and host immune responses in a mouse model of multiple sclerosis.

Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

This study shows that Salmonella-based cancer therapy impairs T cell metabolism, which is linked to its anti-tumor effects.

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection

This study develops a biparatopic anti-TNFR2 antagonist that binds in a 1:1 ratio, preventing unwanted signal transduction and suppressing regulatory T cell proliferation.

Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

The paper identifies a novel liver-specific ILC1 subset lacking IL-7 receptor that develops from fetal liver progenitors and exhibits constitutive cytotoxic activity.

Small RNAs couple embryonic developmental programs to gut microbes

This study shows that maternal gut microbes induce additional embryonic cell divisions in C. elegans through RNAi and miR-35, challenging the idea of an invariant cell lineage.

Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition

This study shows CREB3L3 protects against atherosclerosis by inhibiting SREBP activity through competitive antagonism, reducing lipogenic and cholesterogenic gene expression.

Cellular polarity asymmetrically functionalizes pathogen recognition receptor-mediated intrinsic immune response in human intestinal epithelium cells

The paper shows that AP-1B-mediated polarized sorting of TLR3 leads to an asymmetric immune response in human intestinal epithelial cells to basolateral vs. apical infections.

Attenuated Salmonella typhimurium cancer therapy has direct effects on the tumor epithelium in colorectal cancer

Attenuated Salmonella typhimurium reduces tumor burden in mice by directly affecting the tumor epithelium through transcriptional and metabolic changes.