K. Ishikawa

Contactless metabolism estimation of small animals using high-frequency millimeter-wave radar

This study develops a system to estimate oxygen consumption in small animals using millimeter-wave radar and machine learning, enabling contactless and low-cost measurements.

Arrayed CRISPRi library to suppress genes required for Schizosaccharomyces pombe viability

The paper constructs CRISPRi libraries to knock down essential genes in S. pombe, revealing metabolic pathway interactions and enabling functional studies of essential genes.

Characterization and contribution of RPE senescence to Age-related macular degeneration in Tnfrsf10 knock out mice

This study investigates how RPE senescence contributes to AMD using TNFRSF10A silenced hRPE cells and Tnfrsf10 KO mice, showing increased p16 and p21 expression and metabolic changes.

A mechanism of melanogenesis mediated by E-cadherin downregulation and its involvement in solar lentigines

This study identifies E-cadherin downregulation as a mechanism driving melanogenesis in age spots and shows that Rosa multiflora extract can upregulate E-cadherin in keratinocytes.

Genetic differentiation of water penny beetles may be associated with the formation process of the ancient Lake Biwa.

This study investigates genetic differentiation in water penny beetles around Lake Biwa, finding that E. ramicornis diverged 1.4 MYA while E. granicollis showed no genetic differentiation.

Knockout of ribosomal protein RpmJ leads to zinc resistance in Escherichia coli

The paper identifies RpmJ knockout in E. coli as a zinc-resistant mutation, showing decreased intracellular zinc and altered gene expression related to iron-sulfur clusters.

Knockout of ykcB, a putative glycosyltransferase, leads to vancomycin resistance in Bacillus subtilis

This study identifies ykcB knockout in Bacillus subtilis as a cause of vancomycin resistance, with associated changes in cell surface composition and increased pathogenicity.

Apoplastic CBM1-interacting proteins bind conserved carbohydrate binding module 1 motifs in fungal hydrolases to counter pathogen invasion

The paper identifies OsCBMIP, a rice protein that binds to fungal CBM1 domains in xylanases, inhibiting their activity and enhancing rice defense against M. oryzae.

Structural analysis and construction of thermostable antifungal chitinase

This paper reports the structural analysis of a chitinase from Ficus microcarpa latex and constructs a thermostable mutant with improved activity and stability through rational protein engineering.

Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model

This paper identifies a small molecule that targets toxic RNA repeats in a Drosophila model of SCA31, reducing RNA foci and alleviating disease symptoms.

SNF1-related protein kinase 2 directly regulate group C Raf-like protein kinases in abscisic acid signaling

This study identifies Raf36 as a SnRK2-interacting kinase that negatively regulates ABA responses and is directly phosphorylated by SnRK2s, revealing a new phosphosignaling pathway in ABA signaling.