Y. Nagai

This study reconstitutes G4C2 repeat-associated non-AUG translation using purified human factors and identifies key features of the process.

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

The paper demonstrates that focal adhesion membrane is partitioned into compartments where molecules undergo hop diffusion, with protein islands acting as dynamic hubs for integrin interactions.

This paper develops an ultrafast camera system for single fluorescent-molecule imaging and live-cell PALM, achieving high temporal and spatial resolution for studying cellular dynamics.

MeDUsA automates axon quantification in Drosophila to assess neuroaxonal degeneration, showing axonal degeneration occurs with ND-related proteins but not correlated with REP.

This paper identifies a small molecule that targets toxic RNA repeats in a Drosophila model of SCA31, reducing RNA foci and alleviating disease symptoms.

This study sequenced the genome of a kleptoplastic sea slug and found no evidence of algal gene transfer to the nucleus, showing photosynthesis can occur without nuclear gene transfer.

This paper develops a transgenic mouse expressing QBP1 to block traumatic memory consolidation, showing impaired aversive memory and reduced amyloid oligomerization.