Pharmacology & ToxicologybioRxiv
Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry
W.-H. Guo, X. Qi, X. Yu…·J. Wang
This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.
DOI 10.1038/s41467-020-17997-6